[1]高 扬,李佳璞,杨来侠,等.可降解药物控释系统的药物扩散系数表征[J].西安科技大学学报,2018,(06):1021-1026.[doi:10.13800/j.cnki.xakjdxxb.2018.0620]
 GAO Yang,LI Jia-pu,YANG Lai-xia,et al.Diffusion coefficient expression of degradable controlled drug delivery system[J].Journal of Xi'an University of Science and Technology,2018,(06):1021-1026.[doi:10.13800/j.cnki.xakjdxxb.2018.0620]
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可降解药物控释系统的药物扩散系数表征(/HTML)
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西安科技大学学报[ISSN:1672-9315/CN:61-1434/N]

卷:
期数:
2018年06期
页码:
1021-1026
栏目:
出版日期:
2018-11-30

文章信息/Info

Title:
Diffusion coefficient expression of degradable controlled drug delivery system
文章编号:
1672-9315(2018)06-1021-06
作者:
高 扬1李佳璞1杨来侠1徐 超1董贵荣2
(1.西安科技大学 机械工程学院,陕西 西安 710054; 2.西安理工大学 高等技术学院,陕西 西安 710082)
Author(s):
GAO Yang1LI Jia-pu1YANG Lai-xia1XU Chao1DONG Gui-rong2
(1.College of Mechanical and Engineering,Xi'an University of Science and Technology,Xi'an 710054,China; 2.The Faculty of High Vocational Education,Xi'an University of Technology,Xi'an 710082,China)
关键词:
机械工程 可降解材料 给药系统 体外释药 扩散系数
Keywords:
mechanical engineering degradable material controlled drug delivery system in-vitro release diffusion coefficient
分类号:
O 631.2
DOI:
10.13800/j.cnki.xakjdxxb.2018.0620
文献标志码:
A
摘要:
为实现药物的长期稳定释放并提高药物利用率,提出了一种以聚乳酸-聚羟基乙酸(PLGA)为载药基体的新型植入式药物控释系统。该药物控释系统可埋植在病灶附近进行长期释药,在药物释放结束后药物载体自然降解。为研究该药物控释系统的释药性能,建立其药物释放模型、模拟释药过程是有效方法之一,但在建立药物释放模型过程中,不断降解的PLGA材料特性难以量化。文中提出了一种使用扩散系数来表征PLGA材料的降解溶蚀程度的方法,在37 ℃下使用生理盐水模拟体液,对50/50、65/35及75/25三种单体比例的PLGA材料进行吸水实验和降解实验,并制备全封装药物控释系统进行了体外释药实验。通过实验结果的对比并基于物质守恒与传递定理,推导了封装药物在PLGA载药基体中释放时扩散系数的分段表达函数。基于该扩散系数表达函数,建立了药物通过该给药系统释放的有限元模型; 使用有限元模型模拟药物的释放过程,并将有限元模拟结果与该药物控释系统体外释药实验结果进行了对比。结果表明,药物控释系统累积释药量呈线性变化,有限元模型模拟结果与体外释药实验结果基本吻合,验证了药物在PLGA材料中扩散系数分段表达式及有限元释药模型的正确性。该研究为后期建立药物释放的解析模型提供了一定的理论基础。
Abstract:
To control and curb chronic diseases,the long-term and stable drug release is important.In this paper,the controlled drug delivery system(CDDS)which made by poly(lactic-co-glycolic acid)(PLGA)was proposed.CDDS could be implanted around lesions and released drug continuously,the PLGA drug carrier will be degraded to water and carbon dioxide after loaded drug exhausted.To research the CDDS drug release characteristics,establishment of drug release model is one of effective method.In drug release process however,the features of continuous degradation PLGA were difficult to be quantified,so the diffusion coefficient was used to express the degree of PLGA erosion.Three monomers 50/50,65/35and 75/25PLGA absorb water,degradation and drug release in-vitro experiments were carried out at 37℃,normal saline was used to imitate body fluid.On the basis of the above experiments and material transfer theorem,the piecewise function of drug diffusion coefficient in PLGA was deducted.The drug releasing FEM model was established based on the drug diffusion coefficient function,and the drug release process was simulated.The reasonableness of the drug diffusion coefficient function is verified by the results comparison of FEM drug release model and in-vitro drug release experiment.The research provides the theoretical basis for the establishment of drug release model.

参考文献/References:


[1] XIE Mao-bin,FAN De-jun,CHEN Yu-feng.An implantable and controlled drug-release silk fibroin nanofibrous matrix to advance the treatment of solid tumour cancers[J].Biomaterials,2016,103:33-43.
[2]Hoffman A S.The origins and evolution of “controlled” drug delivery systems[J].Journal of Controlled Release,2008,132:153-163.
[3]赵天倚,赵继鹏,雷莉妍.可降解聚合物包覆次血红素六肽微球的制备及生物活性[J].高等学校化学学报,2013,34(1):236-241. ZHAO Tian-yi,ZHAO Ji-peng,LEI Li-yan.Preparation and bioactivities of dhhp-6-loaded biodegradable polymeric microspheres[J].Chemical Journal of Chinese Universities,2013,34(1):236-241.
[4]Kasuya K,Takagi K,Ishiwatari S.Biodegradabilities of various aliphatic polyesters in natural waters[J].Polymer Degradation and Stability,1998,59(1):327-332.
[5]Siparsky G L,Voorhees K J,Miao F.Hydrolysis of polylactic acid(PLA)and polycaprolactone(PCL)in aqueous acetonitrile solutions:autocatalysis[J].Journal of Environmental Polymer Degradation,1998,6(1):31-41.
[6]Lothar W Kleine,Jeremy C Wright,WANG Yun-bing.Evolution of implantable and insertable drug delivery systems[J].Journal of Controlled Release,2014,181:1-10.
[7]洪伟勇,章文红,王石健.生物可降解纳米药物转运系统研究进展[J].实用药物与临床,2015,18(5):607-610. HONG Wei-yong,ZHANG Wen-hong,WANG Shi-jian.Development of biodegradable polymeric nanoparticles based drug delivery systems[J].Practical Pharmacy and Clinical Remedies,2015,18(5):607-610.
[8]Bertram J P,Rauch M F,Chang K.Using polymer chemistry to modulate the delivery of neurotrophic factors from degradable microspheres:delivery of BDNF[J].Pharmaceutical Research,2010,27(1):82-91.
[9]Zolnik B S,Burgess D J.Effect of acidic PH on PLGA microsphere degradation and release[J].Journal of Controlled Release,2007,122(3):338-344.
[10]王 峰,涂家生,张钧寿,等.PLGA微球控释系统的突释及其控制[J].药学进展,2003,27(3):142-146. WANG Feng,TU Jia-sheng,ZHANG Jun-shou,et al.Study on initial burst release in PLGA microspheres controlled delivery systems[J].Progress in Pharmaceutical Sciences,2003,27(3):142-146.
[11]叶美娣,郑彩虹.乳酸-羟基乙酸共聚物(PLGA)微球控释系统的突释[J].中国现代应用药学杂志,2005,22(5):372-374. YE Mei-di,ZHENG Cai-hong.The initial burst of PLGA microparticle systems[J].The Chinese Journal of Modern Applied Pharmacy,2005,22(5):372-374.
[12]Ryu W H,Vyakarnam M,Greco R S.Fabrication of multi-layered biodegradable drug delivery device based on micro-structuring of PLGA polymers[J].Biomedical Microdevices,2007,9(6):845-853.
[13]陈 超,陈天宁,王小鹏.生物可降解材料PLGA的应力松弛性能[J].高分子材料科学与工程,2012,28(1):60-62. CHEN Chao,CHEN Tian-ning,WANG Xiao-peng.Stress relaxation properties of biodegradable polymer PLGA[J].Polymer Materials Science and Engineering,2012,28(1):60-62.
[14]GAO Yang,GE Hong-yu,HUO Ya-guang.The model of degradable polymer plga deformed by hot embossing method[J].Advances in Computer Science Research,2015,13:286-289.
[15]王小鹏,陈天宁.可降解高聚物PLGA降解溶蚀的仿真模型[J].高分子材料科学与工程,2012,28(2):174-178. WANG Xiao-peng,CHEN Tian-ning.Degradation and erosion model of biodegradable PLGA[J].Polymer Materials Science and Engineering,2012,28(2):174-178.
[16]HAN Xiao-xiao,PAN Jing-zhe.Polymer chain scission,oligomer production and diffusion:a two-scale model for degradation of bioresorbablepolyesters[J].Acta Biomaterialia,2011,7(2):538-547.
[17]CHEN Yu-han,ZHOU Shi-wei,LI Qing.Mathematical modeling of degradation for bulk-erosive polymers:applications in tissue engineering scaffolds and drug delivery systems[J].Acta Biomaterialia,2011,7(3):1140-1149.
[18]关 睿,陈天宁,王小鹏.用于微结构成型的新型热压机温度控制系统研究[J].机电工程技术,2010,39(1):16-18. GUAN Rui,CHEN Tian-ning,WANG Xiao-peng.Research on temperature control system of hot-embossing equipment for polymer micro-structure[J].Mechanical and Electrical Engineering Technology,2010,39(1):16-18.
[19]E.L.柯斯乐.扩散流体系统中的传质[M].北京:化学工业出版社,2002. Cussler E L.Diffusion mass transfer in fluid system[M].Beijing:Chemical Industry Press,2002.
[20]Charlier A,Leclerc B,Couarraze G.Release of mifepristone from biodegradable matrices:experimental and theoretical evaluations[J].International Journal of Pharmaceutics,2000,200:115-120.
[21]Ryu W H.Micro-fabrication techonlogy for biodegradable polymers and its application[D].Palo Alto:Stanford Universiy,2005.

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备注/Memo

备注/Memo:
收稿日期:2018-03-06 责任编辑:高 佳
基金项目:国家自然科学基金(51605379); 国家高技术研究发展计划(863)(2015AA042503); 陕西省教育厅科研计划(15JK1484)
通信作者:杨来侠(1961-),女,陕西耀县人,教授,博士生导师,E-mail:867368760@qq.com
更新日期/Last Update: 2018-11-15